Jurnal

Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice

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We investigated the role of insulin receptor substrate (Irs)-1 for diethylnitrosamine (DEN) plus high-fat (HF) diet-induced hepatic tumorigenesis in mice. We gave DEN by intraperitoneal injection at the dose of 80 mg/kg to 18-week-old wild-type (WT) and Irs1-knockout (Irs1-/-) mice, which were fed a HF diet from 8 weeks-of-age until they were killed (52 weeks). The Irs1-/- mice showed significantly lower plasma alanine aminotransferase levels, triglyceride contents in the liver and also lower expression levels of the genes encoding inflammatory cytokines than the WT mice. The incidence of DEN plus HF dietinduced hepatic tumors was 71.4% in the WT mice, whereas it was just 14.3% in the Irs1-/- mice. The present study showed that Irs1 played an important role in DEN plus HF diet-induced hepatic tumorigenesis.

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Detail Information

Series Title

JDI Jurnal of Diabetes Investigation Volume 5, Issue 1 January 2014

Call Number

(05) 616.46 WIL j

Publisher

Australia : Wiley., 2014

Collation

Hlm. 27-30

Language

English

ISBN/ISSN

2040-1124

Classification

(05) 616.46 WIL j

Content Type

-

Media Type

-

Carrier Type

-

Edition

Volume 5, Issue 1

Subject(s)

Diethylnitrosamine
Hepatic tumorigenesis
Insulin receptor substrate-1

Specific Detail Info

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